TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.
نویسندگان
چکیده
New cysteine proteinase inhibitors, TMC-52A, B, C, and D, were isolated from the fungal fermentation broth. On the basis of a taxonomical study, the producing strain, F-2665, was characterized as Gliocladium sp. Spectroscopic analyses and chemical degradation have shown TMC-52A to D to be epoxysuccinyl peptides. TMC-52A to D strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 values of 13 nM, 10nM, 10nM, and 6nM, respectively.
منابع مشابه
GLISOPRENINS, NEW INHIBITORS OF ACYL-CoA: CHOLESTEROL ACYLTRANSFERASE PRODUCED BY Gliocladium sp. FO-1513 I. PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES HlROSHI TOMODA, XlN-Hui HUANG, HlROYUKI NlSHIDAf, ROKURO MASUMA,
Gliocladium sp. FO-1513 was found to produce novel inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Twoactive compounds, designated glisoprenins A and B, were isolated from the culture broth of the producing strain by a conventional method. The IC50 values of glisoprenins A and B for ACATactivity were 46 and 61fiM in an enzyme assay using rat liver microsomes, and 1.2 and 0.57 /^M in...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 51 7 شماره
صفحات -
تاریخ انتشار 1998